Crystal Structure and Physicochemical Characteristics of Two Novel Adamantane Derivatives of Sulfonamides

Abstract: Two derivatives of adamantane benzenesulfamide have been synthesized and studied: N-adamantane-1-yl-2,4,6-trimethyl-benzenesulfamide (1) and N-adamantane-1-yl-4-methoxy-benzenesulfamide (2). Crystal structures 1 and 2 are solved using X-ray diffraction (XRD) analysis. The solubilities of compounds in a phosphate buffer solution with pH 7.4, 1-octanol, and n-hexane are determined at several temperature points using isothermal saturation. The values of Gibbs energy, enthalpy, and entropy of solubility of the compounds at 298 K are determined. © 2021, Pleiades Publishing, Inc.

Authors
Kovalchukova O.V. 1 , Kazachenko V.P.2 , Tkachev V.V. 2, 3 , Utenyshev A.N. 3, 4 , Strakhova N.N.2 , Proshin A.N.2
Journal
Crystallography Reports
Number of issue
3
Language
English
Pages
424-428
Status
Published
Link
External link
DOI
10.1134/S1063774521030123
Volume
66
Year
2021
Organizations
  • 1 Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 2 Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow oblast 142432, Russian Federation
  • 3 Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast 142432, Russian Federation
  • 4 Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russian Federation
Keywords
Amides; Hexane; Solubility; Sulfur compounds; X ray diffraction analysis; 1-octanol; Adamantane derivatives; Adamantanes; Isothermal saturation; Methoxy; N hexane; Phosphate buffer solutions; Physicochemical characteristics; Crystal structure
Date of creation
20.07.2021
Date of change
20.07.2021
Short link
https://repository.rudn.ru/en/records/article/record/74307/
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