Biodistribution of10 b in glioma orthotopic xenograft mouse model after injection of l-para-boronophenylalanine and sodium borocaptate

Boron neutron capture therapy (BNCT) is based on the ability of the boron-10 (10 B) isotope to capture epithermal neutrons, as a result of which the isotope becomes unstable and decays into kinetically active elements that destroy cells where the nuclear reaction has occurred. The boron-carrying compounds—L-para-boronophenylalanine (BPA) and sodium mercaptoundecahydro-closo-dodecaborate (BSH)—have low toxicity and, today, are the only representatives of such compounds approved for clinical trials. For the effectiveness and safety of BNCT, a low boron content in normal tissues and substantially higher content in tumor tissue are required. This study evaluated the boron concentration in intracranial grafts of human glioma U87MG cells and normal tissues of the brain and other organs of mice at 1, 2.5 and 5 h after administration of the boron-carrying compounds. A detailed statistical analysis of the boron biodistribution dynamics was performed to find a ‘window of opportunity’ for BNCT. The data demonstrate variations in boron accumulation in different tissues depending on the compound used, as well as significant inter-animal variation. The protocol of administration of BPA and BSH compounds used did not allow achieving the parameters necessary for the successful course of BNCT in a glioma orthotopic xenograft mouse model. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Authors
Gubanova N.V.1 , Tsygankova A.R.2, 3 , Zavjalov E.L.1 , Romashchenko A.V.1 , Orlov Y.L. 1, 3, 4, 5
Journal
Publisher
MDPI AG
Number of issue
7
Language
English
Status
Published
Number
722
Volume
9
Year
2021
Organizations
  • 1 Institute of Cytology and Genetics, Siberian Branch Russian Academy of Sciences, Novosibirsk, 630090, Russian Federation
  • 2 Nikolaev Institute of Inorganic Chemistry, Siberian Branch Russian Academy of Sciences, Novosibirsk, 630090, Russian Federation
  • 3 Department of Natural Sciences, Novosibirsk State University, Novosibirsk, 630090, Russian Federation
  • 4 Agrarian and Technological Institute, Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
  • 5 The Digital Health Institute, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, 119911, Russian Federation
Keywords
BNCT; Boron neutron capture therapy; BPA; BSH; Glioma; L-para-boronophenylalanine; Mouse model; Sodium borocaptate
Date of creation
20.07.2021
Date of change
15.03.2022
Short link
https://repository.rudn.ru/en/records/article/record/74179/
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