Data on association of mitochondrial heteroplasmy and cardiovascular risk factors: Comparison of samples from Russian and Mexican populations

Despite the fact that the role of mitochondrial genome mutations in a number of human diseases is widely studied, the effect of mitochondrial heteroplasmy in the development of cardiovascular disease has not been adequately investigated. In this study, we compared the heteroplasmy levels of mtDNA from leukocytes for m.3256C>T, m.3336T>C, m.12315G>A, m.5178C>A, m.13513G>A, m.14459G>A, m.14846G>A, m.15059G>A, m.652insG and m.1555A>G mutations in CVD-free subjects and CVD patients in samples derived from Russian and Mexican populations. It was demonstrated that heteroplasmy level of m.5178C>A was associated with CVD in Russian men, and m.14459G>A – in Russian women. Mitochondrial heteroplasmy level of m.13513G>A and m.652insG were associated with CVD in Mexican men, and only m.652insG– in Mexican women. The levels of heteroplasmy for mitochondrial mutations m.3336T>C, m.5178C>A, m.14459G>A, m.14846G>A and m.1555A>G were significantly higher in CVD-free Mexican men, and for m.3256C>T, m.3336T>C, and m.14459G>A – in CVD-free Mexican women. © 2018 The Authors

Authors
Kirichenko T.V.2 , Sobenin I.A.2 , Khasanova Z.B.2 , Orekhova V.A.2 , Melnichenko A.A.3 , Demakova N.A.3 , Grechko A.V. 4 , Orekhov A.N.5, 6 , Ble Castillo J.L.7 , Shkurat T.P.3
Journal
Publisher
Elsevier Inc.
Language
English
Pages
16-21
Status
Published
Volume
18
Year
2018
Organizations
  • 1 Peoples’ Friendship University of Russia
  • 2 National Research Medical Center of Cardiology
  • 3 Southern Federal University
  • 4 Federal Scientific Clinical Center for Resuscitation and Rehabilitation
  • 5 Institute of General Pathology and Pathophysiology
  • 6 Skolkovo Innovation Center
  • 7 Autonomous University Juarez of Tabasco
Keywords
Atherosclerosis; Cardiovascular risk factors; Coronary heart disease; Heteroplasmy; Mitochondrial mutations
Date of creation
14.05.2021
Date of change
14.05.2021
Short link
https://repository.rudn.ru/en/records/article/record/73408/
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