Possibilities for systemic enzyme therapy in patients with chronic endometritis after missed abortion

Objective. To evaluate the effectiveness of systemic enzyme therapy in patients with chronic endometritis after missed abortion on the basis of morphological and immunohistochemical studies. Materials and methods. The study included 37 reproductive-aged women with missed miscarriage. Wobenzym was used in rehabilitation therapy after artificial abortion in 30 women. The conditions of the endometrium was studied by morphological and immunohistochemical methods before and after rehabilitation therapy. Results. The morphological signs of chronic inflammation were eliminated during the treatment with preparation Wobenzym; their elimination is confirmed by a decrease in the expression of HLA-DR and the disappearance of CD16+, CD20+, NK-lymphocytes and B-lymphocytes in the stroma. Indifferent endometrium in patients treated with Wobenzym was detected only in 6.7% of cases, secretory endometrium was detected in 73.3% of women, proliferative endometrium – in 26.7%. Conclusion. The use of Wobenzym after instrumental abortion in patients with endometritis and undeveloped pregnancy eliminates morphological signs of inflammation and promotes endometrial regeneration. © A group of authors, 2020.

Authors
Publisher
ООО «Бионика Медиа»
Number of issue
12
Language
Russian
Pages
186-193
Status
Published
Volume
2020
Year
2020
Organizations
  • 1 Peoples Friendship University of Russia, Ministry of Education and Science of Russia, 8 Miklukho-Maklaya str, Moscow, 117198, Russian Federation
  • 2 I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russian Federation
Keywords
Chronic endometritis; Missed abortion; Systemic enzyme therapy; Wobenzym
Date of creation
20.04.2021
Date of change
20.04.2021
Short link
https://repository.rudn.ru/en/records/article/record/72510/
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