Sequential and direct multicomponent reaction (MCR)-based dearomatization strategies

Dearomatization strategies in a multicomponent fashion often result in complex heterocyclic frameworks, which have attracted the attention of chemists due to their natural product-like structures. The combination of these two processes can easily achieve extended molecular complexity and diversity from simple starting materials with high atom economy. Thus, this field has attracted extensive interest owing to its potential significance in both asymmetric catalysis and convenient build-up of libraries of molecules with novel three-dimensional scaffolds, which may find application in medicinal chemistry. Accordingly, a systematic review on this topic will provide the synthetic organic community with a conceptual overview and comprehensive understanding of the different multicomponent reaction (MCR) cascades involving dearomatization as the characteristic step. In addition, this review will help researchers to look at this promising area from a different perspective with respect to drug discovery, new MCR-based disconnections and often hidden opportunities. This journal is. © The Royal Society of Chemistry.

Authors
Sharma U.K.1 , Ranjan P.1 , Van Der Eycken E.V. , You S.-L.3
Publisher
Royal Society of Chemistry
Number of issue
23
Language
English
Pages
8721-8748
Status
Published
Volume
49
Year
2020
Organizations
  • 1 Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, Leuven, B-3001, Belgium
  • 2 Peoples' Friendship University of Russia, Rudn University, 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation
  • 3 State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, China
Keywords
Scaffolds; Asymmetric catalysis; Dearomatization; Medicinal chemistry; Molecular complexity; Multi-component reactions; Natural products; Systematic Review; Three dimensional scaffold; Aromatization
Date of creation
20.04.2021
Date of change
20.04.2021
Short link
https://repository.rudn.ru/en/records/article/record/72430/
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