Effects of dietary p-coumaric acid on the growth performance, digestive enzyme activity, humoral immunity and immune-related gene expression in common carp, Cyprinus carpio

The efficacy of p-coumaric acid (CA) on growth performance, digestive enzyme activity, humoral immunity and immune gene expressions of common carp (Cyprinus carpio) was tested in the present study. Fish were fed diets supplemented with 0, 0.5, 1 and 1.5 g/kg CA for 56 days. According to regression analysis, specific growth rate (SGR), feed conversion ratio (FCR) and weight gain (WG%) were polynomially related to dietary CA levels. The optimum p-coumaric acid supplementation level, based upon these parameters, was 1.35%–1.44%. Furthermore, dietary CA supplementation at levels of 1.0 and 1.5 g/kg significantly improved the serum immune parameters (total Ig, lysozyme and ACH50). Dietary CA especially at 1.0 and 1.5 g/kg increased the intestinal IL-8 and TNF-α, while not affecting the expression of IL-1β and lysozyme gene. The highest and lowest mortality rates 14 days postchallenge with A. hydrophila were recorded in fish fed control and 1.5 g/kg CA, respectively. In conclusion, the oral administration of CA especially at 1 and 1.5 g/kg inclusion levels has the potential to improve growth performance, digestive enzyme activity and immune responses of common carp. © 2021 John Wiley & Sons Ltd

Ahmadifar E.1 , Kalhor N.2 , Dawood M.A.O.3 , Ahmadifar M.4 , Shahriari Moghadam M. , Yousefi M. 6
Blackwell Publishing Ltd
  • 1 Department of Fisheries, Faculty of Natural Resources, University of Zabol, Zabol, Iran
  • 2 Department of Mesanchymal Stem Cell, Academic Center for Education, Culture and Research, Qom Branch, Qom, Iran
  • 3 Department of Animal Production, Faculty of Agriculture, Kafrelsheikh University, Kafrelsheikh, Egypt
  • 4 Department of Stem Cell Biology and Technology of ACECR, Royan Institute, Cell Science Research Center, Collage of Stem Cell and Developmental Biology, Tehran, Iran
  • 5 Department of Environmental Sciences, Faculty of Natural Resources, University of Zabol, Zabol, Iran
  • 6 Department of Veterinary Medicine, Peoples' Friendship University of Russia (RUDEN University), Moscow, Russian Federation
A. hydrophila; common carp; digestive enzyme; health; immune response; p-coumaric acid
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