Promising applications of steroid сonjugates for cancer research and treatment

The conjugation of biologically active molecules is a powerful tool for drug discovery used to target a variety of multifunctional diseases including cancer. Conjugated drugs can provide combination therapies in a single multi-functional agent and, by doing so, be more specific and powerful than conventional classic treatments. Steroids are widely used for conjugation with other biological active molecules. This review refers to investigations of steroid conjugates as potential anticancer agents carried out mostly over the past decade. It consists of five parts in which the data concerning structure and anticancer activity of steroid conjugates with DNA alkylating agents, metallocomplexes, approved drugs, some biological active molecules, some natural compounds and related synthetic analogs are described. © 2020 Elsevier Masson SAS

Authors
А. Zolottsev V. , Latysheva А.S.1 , Pokrovsky V.S. 2, 3 , Khan I.I. 2, 3 , Misharin A.Y.1
Journal
European Journal of Medicinal Chemistry
Publisher
Elsevier Masson SAS
Language
English
Status
Published
Link
External link
DOI
10.1016/j.ejmech.2020.113089
Number
113089
Volume
210
Year
2021
Organizations
  • 1 V.N. Orekhovich Institute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow, 119435, Russian Federation
  • 2 N.N. Blokhin National Medical Research Center of Oncology of Ministry of Health of Russian Federation, 24 Kashirskoye Highway, Moscow, 115478, Russian Federation
  • 3 RUDN University, 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation
Keywords
Anticancer activity; Antiproliferative activity; Steroid conjugates
Date of creation
20.04.2021
Date of change
20.04.2021
Short link
https://repository.rudn.ru/en/records/article/record/72189/
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