The effect of: Plantago major supplementation on leptin and VEGF-A serum levels, endothelial dysfunction and angiogenesis in obese women-a randomised trial

Obesity is associated with increased serum leptin level, endothelial dysfunction and angiogenesis. In vitro studies have shown that vascular endothelial growth factor (VEGF) synthesis is increased by leptin. Animal studies revealed the effectiveness of Plantago supplementation treatment of obesity. The study aim was to evaluate the effect of Plantago major supplementation on serum leptin and VEGF blood concentration, endothelial dysfunction and angiogenesis in obese women. Seventy-two obese women received oral Plantago major supplement (Plantago group, n = 35) or placebo (placebo group, n = 37) for 12 weeks. At baseline and after completion, anthropometric and body composition measurements were performed, and blood samples were collected. Serum concentrations of leptin, VEGF-A, adiponectin, tumour necrosis factor α and soluble intercellular adhesion molecule have been determined. At completion, the leptin level was higher in the Plantago group (39781.55 ± 20360.73 pg ml-1) compared to both the baseline (36138.71 ± 25401.51 pg ml-1) and placebo group (30502.81 ± 19003.18 pg ml-1). Also, leptin concentration in the Plantago group at completion correlated positively with an increase in VEGF-A level (R = 0.45), and baseline VEGF-A level correlated negatively with the increase in leptin concentration (R =-0.47). Plantago major supplementation increases leptin serum level, enhances leptin influence on VEGF-A serum level increase and by this mechanism may intensify endothelial dysfunction and angiogenesis in obese women. © 2021 The Royal Society of Chemistry.

Skrypnik D.1 , Skrypnik K.2 , Pelczyńska M.1 , Sobieska M.3 , Tinkov A.A. 4, 5, 6 , Suliburska J. 2 , Bogdański P. 1
Royal Society of Chemistry
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  • 1 Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznań University of Medical Sciences, Szamarzewskiego St 84, Poznań, 60-569, Poland
  • 2 Department of Human Nutrition and Dietetics, Poznań University of Life Sciences, Wojska Polskiego St 31, Poznań, 60-624, Poland
  • 3 Department of Physiotherapy, Department for Physiotherapy and Rehabilitation, Poznań University of Medical Sciences, 28. Czerwca 1956r St 135/147, Poznań, 61-545, Poland
  • 4 Department of Medical Elementology, Peoples' Friendship University of Russia, Rudn University, Moscow, 117198, Russian Federation
  • 5 Laboratory of Biotechnology and Applied Bioelementology, Yaroslavl State University, Yaroslavl, 150003, Russian Federation
  • 6 Laboratory of Molecular Dietology, Im Sechenov First Moscow State Medical University, Moscow, 119146, Russian Federation
Biochemistry; Blood; Cell adhesion; Cell death; Nutrition; Blood concentrations; Body composition; Endothelial dysfunction; Intercellular adhesion molecules; Placebo groups; Serum concentration; Tumour necrosis factor alphas; Vascular endothelial growth factor; Hormones
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