Synthesis of spiroindolenines by intramolecular: Ipso -iodocyclization of indol ynones

A high-yielding fast spirocyclization of easily available indol ynones has been developed by applying N-iodosuccinimide. The formation of the desired product occurs in an atom-economical way, under mild conditions, instantly after the addition of the reagent. The expected 1,2-rearrangement was not observed. The procedure represents a metal free spirocyclization of indoles with an opportunity for further functionalizations. © 2018 The Royal Society of Chemistry.