Efficiency of chemotherapy with bedaquiline in drug resistant pulmonary tuberculosis patients

The objective: to evaluate the efficiency of chemotherapy with bedaquiline in pulmonary tuberculosis patients with multiple drug resistance. Subjects and methods. The chemotherapy efficiency was studied in 70 tuberculosis patients with extensive (XDR) or multiple (MDR) drug resistance who were treated in clinics of Central Tuberculosis Research Institute. All patients were divided into 3 groups: Group 1 (10 persons) included MDR TB patients, Group 2 (32 persons) included pre-XDR TB patients, Group 3 (28 persons) included XDR TB patients. Results of the study. High treatment efficiency in this difficult category of pulmonary tuberculosis patients with MDR and XDR was achieved when bedaquiline was added to the chemotherapy regimen. Upon the completion of the main treatment course with bedaquiline, in the group of patients with MDR and pre-XDR the sputum conversion was achieved in 100%, and in XDR tuberculosis patients the sputum conversion rate made 89.3%. The long-term treatment course with bedaquiline promoted the fastest sputum conversion, healing of cavities in the lungs of patients with disseminated tuberculosis and XDR, and it was not associated with a higher frequency of adverse events. © 2018 New Terra Publishing House. All rights reserved.

Authors
Tikhonov A.M.1 , Burakova M.V. 1, 2 , Vaniev E.V.3 , Romanov V.V.1 , Vasilyeva I.A.3
Publisher
New Terra Publishing House
Number of issue
2
Language
Russian
Pages
22-26
Status
Published
Volume
96
Year
2018
Organizations
  • 1 Central Research Institute of Tuberculosis, Tuberculosis Control Department, 2, Yauzskaya Alleya, Moscow, 107564., Russian Federation
  • 2 People's Friendship University of Russia, Moscow, Russian Federation
  • 3 National Medical Research Center of Phthisiopulmonology and Infectious Diseases, 4, Dostoevsky St., Moscow, 127473, Russian Federation
Keywords
Chemotherapy efficiency; Drug resistance of tuberculous mycobacteria; Pulmonary tuberculosis
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/7144/
Share

Other records