The article gives the definition of infectious endocarditis, raises the issues of epidemiology, etiology, classification, and diagnostic criteria of this disease. It also presents the results of the treatment regimens analysis of infectious endocarditis cases for 2014-2017 year in MCH No. 24, Department of Health, addresses the perspective implementation of new drugs. Clinical case of successful treatment of infectious endocarditis, characterized by a variety of clinical manifestations, and, consequently, extended diagnostic search is discussed. In addition, the case of diagnosing endocardial tuberculosis is of scientific interest, because tuberoculous nature is atypical for infectious endocarditis, however, it should be borne in mind that nowadays, due to the increase in the incidence of tuberculosis, such etiology may occur. © 2018 Media Sphera Publishing Group. All rights reserved.