Journal of Materials Chemistry C.
Royal Society of Chemistry.
Vol. 6.
2018.
P. 7677-7682
Unexpected Reaction of Ethyl 4-(Chloromethyl)pyrazolo- [5,1-c][1,2,4]triazine-3-carboxylates with Thiourea and Its Mechanism
The reaction of ethyl 4-(chloromethyl)pyrazolo[5,1-c][1,2,4]triazine-3-carboxylates with thiourea in dimethylformamide involves ANRORC rearrangement (Addition of the Nucleophile, Ring Opening, and Ring Closure) followed by N-formylation to give N-{5-(4-oxo-8-phenyl-1,4-dihydropyrazolo[5,1-c][1,2,4]-triazin-3-yl)-1,3-triazol-2-yl}formamides whose structure was confirmed by X-ray analysis. The reaction mechanism has been studied by HPLC/MS. © 2018, Pleiades Publishing, Ltd.
Authors
Ledenyova I.V.1
,
Falaleev A.V.1
,
Shikhaliev K.S.1
,
Ryzhkova E.A.
2
,
Zubkov F.I.
2
Number of issue
1
Language
English
Pages
73-79
Status
Published
Link
Volume
88
Year
2018
Organizations
- 1 Voronezh State University, Universitetskaya pl. 1, Voronezh, 394006, Russian Federation
- 2 Peoples’ Friendship University of Russia, ul. Miklukho-Maklaya 6, Moscow, 117198, Russian Federation
Keywords
ANRORC rearrangement; ethyl 4-(chloromethyl)pyrazolo[5,1-c][1,2,4]triazine-3-carboxylate; formylation; thiourea
Date of creation
19.10.2018
Date of change
19.10.2018
Share
Other records
Communications in Computer and Information Science.
Springer Verlag.
Vol. 919.
2018.
P. 170-183