Differences in Assessment of the Severity of Depression by Doctors and Patients during Combined Therapy with Agomelatine (the EMOTION multicenter trial)

Objectives. To compare the prognostic value of doctors’ and patients’ assessments of the severity of depression with consideration of treatment outcomes. Materials and methods. The study was organized as a muticenter investigation of 107 patients with depression. Assessments of mental status were preformed using the HAM-D, SHAPS, CGI-S, CGI-I, PGI-S, PGI-I, and VAS. Results. Differences were found between psychiatrists and patients in their assessments of the severity of depression. In addition, doctors’ assessments showed contradictions between the results on the HAM-D and CGI-S scales. Assessments of changes by patients and doctors became more similar as the severity of depression decreased and patients’ wellbeing improved on the background of treatment with agomelatine (Valdoxan). Conclusions. Agomelatine (Valdoxan) was effective and well tolerated in the treatment of depression of any degree of severity. The contradictions in assessment of the initial severity of depression by doctors and patients using different psychometric scales may eliminate the prognostic value of these assessments in relation to treatment outcomes. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Medvedev V.E. 1 , Retyunskii K.Y.2 , Ovchinnikov A.A.3 , Baryl’nik Y.B.4 , Shmilovich A.A.5 , Antokhin E.Y.6 , Usov G.M.7 , Cheremin R.A.8 , Poletskii V.M.9 , Onegin A.V.10 , Kireeva I.P.5 , Frolova V.I. 1 , Filippova N.V.4 , Antonova A.A.4 , Deeva M.A.4 , Onegina D.A.10
Kluwer Academic Publishers-Plenum Publishers
Number of issue
  • 1 Department of Psychiatry, Psychotherapy, and Psychosomatic Pathology, Russian University of the Friendship of the Peoples, Moscow, Russian Federation
  • 2 Department of Psychiatry, Ural State Medical University, Ekaterinburg, Russian Federation
  • 3 Department of Psychiatry, Narcology, and Psychotherapy, Novosibirsk State Medical University, Novosibirsk, Russian Federation
  • 4 Department of Psychiatry, Narcology, Psychotherapy, and Clinical Psychology, Razumskii Saratov State Medical University, Saratov, Russian Federation
  • 5 Department of Psychiatry and Medical Psychology, Pirogov Russian National Research Medical University, Moscow, Russian Federation
  • 6 Department of Clinical and Psychology and Psychotherapy, Orenburg State Medical University, Orenburg, Russian Federation
  • 7 Department of Psychiatry, Narcology, Psychotherapy, and Clinical Psychology, Omsk State Medical Academy, Omsk, Russian Federation
  • 8 Organizational-Methodological and Consultation Department of Psychiatry and Suicide Studies, Department of Healthcare, Moscow, Russian Federation
  • 9 Department of Psychiatry, South Ural State Medical University, Chelyabinsk, Russian Federation
  • 10 Murmansk Regional Psychoneurology Clinic, Murmansk, Russian Federation
agomelatine; depression; scales; severity
Date of creation
Date of change
Short link

Other records