5-Aryl-2-furaldehydes in the synthesis of tetrahydropyrimidinones by Biginelli reaction

5-Aryl-2-furaldehydes, obtained by furfural arylation with arenediazonium salts, react with ethyl acetoacetate or acetylacetone and (thio)- urea in the presence of FeCl3·6H2O as a catalyst. A series of ethyl 4-(5-aryl-2-furyl)-6-methyl-2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidine- 5-carboxylates was obtained. © 2018 Springer Science+Business Media, LLC.

Authors
Vakhula A.R.1 , Horak Y.I.1 , Lytvyn R.Z.1 , Lesyuk A.I.1 , Kinzhybalo V.2 , Zubkov F.I. 3 , Obushak M.D.1
Publisher
Латвийский институт органического синтеза Латвийской академии наук / Springer New York Consultants Bureau
Number of issue
5
Language
English
Pages
545-549
Status
Published
Volume
54
Year
2018
Organizations
  • 1 Ivan Franko National University of Lviv, 6 Kyryla i Mefodiya St., Lviv, 79005, Ukraine
  • 2 Institute of Low Temperature and Structure Research, Wroclaw, 50-422, Poland
  • 3 RUDN University, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
Keywords
5-aryl-2-furaldehydes; Biginelli reaction; Crystal structure; Multicomponent reactions; Pyrimidine derivatives; Tetrahydropyrimidines
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/6682/
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