5-Aryl-2-furaldehydes in the synthesis of tetrahydropyrimidinones by Biginelli reaction

5-Aryl-2-furaldehydes, obtained by furfural arylation with arenediazonium salts, react with ethyl acetoacetate or acetylacetone and (thio)- urea in the presence of FeCl3·6H2O as a catalyst. A series of ethyl 4-(5-aryl-2-furyl)-6-methyl-2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidine- 5-carboxylates was obtained. © 2018 Springer Science+Business Media, LLC.

Authors
Vakhula A.R. 1 , Horak Y.I. 1 , Lytvyn R.Z. 1 , Lesyuk A.I. 1 , Kinzhybalo V. 2 , Zubkov F.I. 3 , Obushak M.D. 1
Journal
Chemistry of Heterocyclic Compounds
Publisher
Латвийский институт органического синтеза Латвийской академии наук / Springer New York Consultants Bureau
Issue number
5
Language
English
Pages
545-549
State
Published
Link
External link
DOI
10.1007/S10593-018-2301-3
Volume
54
Year
2018
Organizations
  • 1 Ivan Franko National University of Lviv, 6 Kyryla i Mefodiya St., Lviv, 79005, Ukraine
  • 2 Institute of Low Temperature and Structure Research, Wroclaw, 50-422, Poland
  • 3 RUDN University, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
Keywords
5-aryl-2-furaldehydes; Biginelli reaction; Crystal structure; Multicomponent reactions; Pyrimidine derivatives; Tetrahydropyrimidines
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