Pharmacological regulation with antioxidants of hepatocyte cytolysis in acute D-galactosamine-induced intoxication

A rat model of D-galactosamine-induced (0.3 g/kg) liver damage is used to study antioxidant and membrane-stabilizing activity of sodium selenite, vitamin E, and their combination (administered per os, daily, for 3 days before intoxication). It is shown that sodium selenite is 300-fold more effective than vitamin E, while their combination exhibits synergism and potentiation of the antioxidant and membrane-stabilizing activities, underlying inhibition of hepatocyte cytolysis. ©1998 Plenum Publishing Corporation.

Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
4
Language
English
Pages
367-369
Status
Published
Volume
125
Year
1998
Organizations
  • 1 Laboratory of Pharmacology, Institute of General and Clinical Pathology, University of Peoples' Friendship, Moscow, Russian Federation
Keywords
Cytolysis; D-galactosanime hydrochloride; Liver; Sodium selenite; Vitamin E
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/664/
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