A simple approach for the synthesis of azocine alkaloids: The total synthesis of megallanesine

A new three step synthetic route to construct azocine ring system using anion chemistry and intramolecular Friedel-Craft reaction of an ester is presented. This method allows synthesis of azocine ring analogues in excellent overall yields. The designed strategy was applied for the synthesis of naturally occurring magallanesine. © 2018 Elsevier Ltd

Authors
Volvoikar P.S.1 , Tilve S.G. 1, 2
Journal
Tetrahedron Letters
Publisher
Elsevier Ltd
Number of issue
26
Language
English
Pages
2567-2569
Status
Published
Link
External link
DOI
10.1016/j.tetlet.2018.05.055
Volume
59
Year
2018
Organizations
  • 1 Department of Chemistry, Goa University, Taleigao PlateauGoa 403206, India
  • 2 Organic Chemistry Department, RUDN University, 6 Miklukcho-Maklaya Str., Moscow, 117198, Russian Federation
Keywords
Alkaloids; Azocine; Intramolecular Friedel-Craft; Isoindolinone; Magallanesine
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/6570/
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