Pharmacopoeial analysis of inulin-containing medicinal plant raw materials and drugs

Background: Today, there are some unresolved issues and discussions concerning inulin quantitative determination in medicinal plant raw materials (MPRM). MPRM containing polyfructans or fructosans (inulin and others) are rather complex multicomponent matrixes with many interacting compounds. The article discusses the prospects for further standardization of inulin-containing pharmacopoeial MPRM that include, in addition to polysaccharides (inulin), other biologically active compounds with pharmacological activity. Materials and Methods: Different types of search tools such as Google scholar, Google, scientific literature, normative documentation of Russian Federation (State Pharmacopoeia of Russian Federation IV edition and others) electronic databases such as e-Library, Scopus, Web of Science, Pubmed had been searched and data obtained. Results: The pharmacopoeial spectrophotometric procedures of inulin determination in the Russian Federation are approved in a version that does not fully satisfy modern standardization criteria. Regulatory changes required in the near future. Conclusion: Undoubtedly, to determine inulin quantitatively, it is necessary to modify the existing spectrophotometric procedures and introduce an additional alternative, more specific HPLC-RID (or similar) ones. © 2020 Phcogj.Com.

Authors
Bokov D.O.1, 2 , Karabeshkin D.I.3 , Samylina I.A.1 , Potanina O.G. 4 , Krasnyuk I.I. 1 , Malinkin A.D.1, 2 , Junior , Kovaleva T.Y.1 , Bobkova N.V.1 , Antsyshkina A.M.1 , Bondar A.A.1 , Evgrafov A.A.1 , Galiakhmetova E.K.5 , Moiseev D.V.6 , Bessonov V.V.2
Journal
Pharmacognosy Journal
Publisher
EManuscript Technologies
Number of issue
2
Language
English
Pages
415-421
Status
Published
Link
External link
DOI
10.5530/pj.2020.12.64
Volume
12
Year
2020
Organizations
  • 1 Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, Russian Federation
  • 2 Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow, 109240, Russian Federation
  • 3 Normal physiology department, Northern State Medical University, 51Troitsky pr., Arkhangelsk, 163000, Russian Federation
  • 4 Pharmaceutical chemistry and pharmacognosy chair, Рeoples’ Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya Street, Moscow, 117198, Russian Federation
  • 5 Department of pharmacognosy, Bashkir state medical University, 3, Lenina str., Ufa, 450008, Russian Federation
  • 6 Chair of Standardization of Medicines, Vitebsk State Medical University, 27, Frunze avenue,, Vitebsk, 210062, Belarus
Keywords
Fructosans; HPLC-RID; Inulin quantitative determination; Polyfructans
Date of creation
02.11.2020
Date of change
02.11.2020
Short link
https://repository.rudn.ru/en/records/article/record/65647/
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