Experimental and clinical justification of the use of probiotic-sorption drugs in veterinary surgery

The wide range of therapeutic effects of silicon dioxide (reduction of endogenous intoxication, normalization of intestinal microbiocenosis, reduction of systemic inflammatory response, activation of detoxification function) makes its use as a matrix in the production of pharmacological drugs for the treatment and prevention of surgical infection by giving an interesting direction for scientific research. The article provides experimental and clinical justification for the use of complex probiotic-sorption drugs in veterinary surgery in the treatment of various forms of surgical infection. Based on the results of the conducted research, the solution of an urgent scientific problem about the mechanisms of formation of microbiocenoses, improvement of methods of diagnosis, prevention and treatment of cats with surgical infections have been achieved. It is established that purulent-inflammatory processes in cats develop against the background of dysbiotic disorders of the microbial ecosystem of the intestinal tract, which has a certain prognostic value. The introduction to treatment regimens of probiotic-sorption drugs proved to be pathogenetically justified, which is confirmed by experimental and clinical studies. © Advanced Scientific Research. All rights reserved.

Authors
Rudenko P. 1, 2 , Vatnikov Y. 1 , Kulikov E. 2 , Sachivkina N. 3 , Karamyan A. 2 , Rudenko A.4 , Rudenko V.1 , Gadzhikurbanov A. 6 , Murylev V.7, 8 , Elizarov P.7, 8 , Mansur T. 5 , Vyalov S. 5 , Troshina N. 2
Publisher
EManuscript Technologies
Number of issue
4
Language
English
Pages
275-287
Status
Published
Volume
11
Year
2020
Organizations
  • 1 Biological Testing Laboratory, Branch of Shemyakin-Ovchinnikov Institute, Bioorganic Chemistry of the Russian Academy of Sciences (BIBCh RAS), 6, Prospekt Nauki, Pushchino, Moscow region, 142290, Russian Federation
  • 2 Department of Veterinary Medicine, Peoples' Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya Street, Moscow, 117198, Russian Federation
  • 3 Department of Microbiology and Virology, Peoples' Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya Street, Moscow, 117198, Russian Federation
  • 4 Department of Veterinary Medicine, Moscow State University of Food Production, 11, Volokolamskoe Highway, Moscow, 125080, Russian Federation
  • 5 Department of General Medical Practice, Peoples' Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya Street, Moscow, 117198, Russian Federation
  • 6 Agroengineering Department, Peoples' Friendship University of Russia (RUDN University), 6, Mklukho-Maklaya Street, Moscow, 117198, Russian Federation
  • 7 Department of Traumatology, Orthopedic and Disaster Medicine, Sechenov First Moscow State Medical University (Sechenov University), 8, Trubetskaya Street, Moscow, 119991, Russian Federation
  • 8 Moscow City Joint Arthroplasty Center, Botkin Moscow City Hospital, 5, 2-i Botkinskii Proezd, Moscow, 125284, Russian Federation
Keywords
Cats; Probiotic; Silicon dioxide; Sorbent; Surgical infection; Veterinary surgery
Date of creation
02.11.2020
Date of change
02.11.2020
Short link
https://repository.rudn.ru/en/records/article/record/65643/
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