Drug-Related Carcinogenesis: Risk Factors and Approaches for Its Prevention

The review summarizes the data on the role of metabolic and repair systems in the mechanisms of therapy-related carcinogenesis and the effect of their polymorphism on the cancer development risk. The carcinogenic activity of different types of drugs, from the anticancer agents to analgesics, antipyretics, immunomodulators, hormones, natural remedies, and non-cancer drugs, is described. Possible approaches for the prevention of drug-related cancer induction at the initiation and promotion stages are discussed. © 2020, Pleiades Publishing, Ltd.

Authors
Belitskiy G.A.1 , Kirsanov K.I. 1, 2 , Lesovaya E.A.1, 3 , Yakubovskaya M.G.1
Language
English
Pages
79-107
Status
Published
Volume
85
Year
2020
Organizations
  • 1 Blokhin Russian Cancer Research Center, Ministry of Health of Russian Federation, Moscow, 115478, Russian Federation
  • 2 Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
  • 3 Pavlov Ryazan State Medical University, Ryazan, 390026, Russian Federation
Keywords
cancer prevention; secondary tumors; therapy-related carcinogenesis
Date of creation
02.11.2020
Date of change
02.11.2020
Short link
https://repository.rudn.ru/en/records/article/record/65547/