Only industrial technologies can provide a high level of profitability of pork production, which provides for year-round keeping of pigs in premises with maximum mechanization and automation of production processes. However, under such conditions, animals are exposed to a whole complex of stress factors, which negatively affects the state of the immune system. As you know, stress occurs when external environmental conditions do not correspond to the internal reserves of the body, which leads to its depletion and the development of a General adaptive syndrome, which is manifested by changes in the behavior of animals, their hormonal status and, especially, the development of immunodeficiency. This causes the development of alimentary anemia, delayed growth and development of piglets, decreased appetite, dyspepsia, gastroenteritis and bronchopneumonia, which brings significant losses to the pig industry. One of the modern directions of research in veterinary practice is the search for environmentally safe preventive means of stimulating nonspecific immunity, mainly of natural origin, and studying their impact on the state of resistance, preservation, growth and productivity of young animals. Among a large number of medicines, the best products are developed on the basis of natural components. Hypericum perforatum has a lot of medical properties. In this regard, we have studied the effect of various doses of the phytopreparation "Deprim", containing an extract of the herb Hypericum perforatum L., on the productivity and safety of piglets and the establishment of its optimal dose in pig farming. This manuscript shows that the use of "Deprim" herbal medicine in piglets in two courses at a dose of 5, 10 and 15 mg / kg of fat contributed to a significant increase in body weight. It was found that after 10 days of giving the herbal medicine, the body weight of animals in the 3 experimental group significantly increased (p<0.01) by 1.06 times, compared to the control group. After 20 days of the experiment, we also observed positive dynamics in the animals only in the piglets of the 3 experimental group – a significant (p<0.05) increase of 1.08 times compared to the control group. It should be noted that in animals of all experimental groups, a month after giving the animals a phytopreparation, its positive effect on the growth of live weight was noted. Thus, 60 day-old piglets of the first, second and third experimental groups had a significant increase in animal body weight of 1.04 (p<0.05); 1.10 (p<0.05) and 1.15 (p<0.001) times, respectively. The prospect of further research is to determine the lymphocytic profile (the content of B-and Tlymphocytes, types of the latter), as well as the level of proinflammatory cytokines in order to establish a more precise mechanism of action of the phytopreparation "Deprim" on the immune system of piglets. © 2020, Advanced Scientific Research. All rights reserved.