The effect of nasal microbiota on the level of total immunoglobulin e in blood serum of children with bronchial asthma

Objective of the research: to study the relationship between the level of total IgE in serum and the nature of the nasal microbiota composition in children with bronchial asthma (BA). Materials and methods: 332 patients with BA were examined, mean age 10,34±0,4 years, 72% boys (239/332), the levels of total IgE and IgA, IgM, IgG in blood serum were determined, the composition of the nasal microbiota was studied by culture method. Results: 21,7% (72/332) of children had no St. aureus and St. epidermidis and other conditionally pathogenic flora in nasal microbiota; in 74,1% (246/332) of children S. aureus or St. epidermidis was revealed, in 40,7% (135/332) of them St. aureus was isolated; in 4,2% (14/332) another conditionally pathogenic microflora was found. The level of total IgE in blood serum in patients who had St. aureus in nasal microbiota was the highest and amounted to 218 [172,5; 264,3] IU/ml (p=0,002). Conclusion: St. aureus on the nasal mucosa of the upper respiratory tract in children with BA is accompanied by a higher level of total IgE in blood serum. © 2020, Pediatria Ltd.. All rights reserved.

Authors
Efimova M.I.1 , Krasilnikova S.V.1 , Ovsyannikov D.Y. 2 , Eliseeva T.I.1 , Bolshova E.V.3 , Nosova T.V.3 , Malysheva L.V.3 , Bulgakova V.A.4, 5, 6 , Balabolkin I.I. 4
Journal
Pediatriya - Zhurnal im G.N. Speranskogo
Number of issue
2
Language
Russian
Pages
56-63
Status
Published
Link
External link
DOI
10.24110/0031-403X-2020-99-2-56-63
Volume
99
Year
2020
Organizations
  • 1 Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation
  • 2 Peoples’ Friendship, University of Russia, Moscow, Russian Federation
  • 3 Children’s City Clinical Hospital № 1 of Nizhny Novgorod, Nizhny Novgorod, Russian Federation
  • 4 National Medical Research Center of Children’s Health, Moscow, Russian Federation
  • 5 Pirogov Russian National Research Medical University, Moscow, Russian Federation
  • 6 I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
Keywords
Allergic rhinitis; Bronchial asthma; Children; Immunoglobulin E; Microbiota; Staphylococci
Date of creation
02.11.2020
Date of change
02.11.2020
Short link
https://repository.rudn.ru/en/records/article/record/64954/
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