Objective of the research: to study the relationship between the level of total IgE in serum and the nature of the nasal microbiota composition in children with bronchial asthma (BA). Materials and methods: 332 patients with BA were examined, mean age 10,34±0,4 years, 72% boys (239/332), the levels of total IgE and IgA, IgM, IgG in blood serum were determined, the composition of the nasal microbiota was studied by culture method. Results: 21,7% (72/332) of children had no St. aureus and St. epidermidis and other conditionally pathogenic flora in nasal microbiota; in 74,1% (246/332) of children S. aureus or St. epidermidis was revealed, in 40,7% (135/332) of them St. aureus was isolated; in 4,2% (14/332) another conditionally pathogenic microflora was found. The level of total IgE in blood serum in patients who had St. aureus in nasal microbiota was the highest and amounted to 218 [172,5; 264,3] IU/ml (p=0,002). Conclusion: St. aureus on the nasal mucosa of the upper respiratory tract in children with BA is accompanied by a higher level of total IgE in blood serum. © 2020, Pediatria Ltd.. All rights reserved.