The effect of immunoprophylaxis of respiratory syncytial viral infection with palivizumab on the development of bronchial asthma in children with bronchopulmonary dysplasia

Prematurity, bronchopulmonary dysplasia (BPD), and respiratory syncytial virus (RSV) infection are risk factors for bronchial asthma (BA) development. Palivizumab is effective in preventing severe cases of RSV infection in children. Objective of the research: to determine the effect of Palivizumab immunization on the risk of BA development in children with BPD. Materials and methods: out of 510 patients with BPD, 34 were diagnosed with BA on the basis of PRACTALL criteria (Practical Allergology Pediatric Asthma Group) with mandatory allergological confirmation, 263 children received from 1 to 5 injections of Palivizumab during the annual epidemiological season of RSV infection. Results: among children with BPD that did not have BA, 222 patients (90,2%) out of 246 received a complete (≥3 injection) course of immunoprophylaxis, while in patients with BA, only 3 (18%) of 17 (p<0,001). Conclusion: BA development in children with BPD is statistically significantly associated with an incomplete course (<3 injections) of prophylaxis of severe RSV infection with Palivizumab, while a full course of immunoprophylaxis (≥3 injections) statistically significantly reduces the risk of BA (p<0,001). © 2020, Pediatria Ltd. All rights reserved.

Number of issue
2
Language
Russian
Pages
63-68
Status
Published
Volume
99
Year
2020
Organizations
  • 1 Peoples’ Friendship University of Russia, Moscow, Russian Federation
  • 2 Federal Scientific Clinical Center of Sports Medicine and Rehabilitation, Federal Biomedical Agency, Moscow, Russian Federation
  • 3 Children’s Infectious Clinical Hospital No 6, Moscow, Russian Federation
  • 4 Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russian Federation
Keywords
Bronchial asthma; Bronchopulmonary dysplasia; Children; Palivizumab; Respiratory syncytial viral infection
Date of creation
02.11.2020
Date of change
02.11.2020
Short link
https://repository.rudn.ru/en/records/article/record/64944/