A Facile One-Pot Synthesis of 1,2,3,4-Tetrahydroisoquinoline-1-carbonitriles via the Electrogenerated Cyanide Anions from Acetonitrile

The electrosynthesis of 1,2,3,4-tetrahydroisoquinoline-1-carbonitriles by acetonitrile reduction is a green and safe strategy to replace the traditional cyanation. Herein, we have obtained the 1,2,3,4-tetrahydroisoquinoline-1-carbonitrile in good yields by a simple reaction between dihydroisoquinolin-2-ium iodide and the electrogenerated acetonitrile formed under low temperature conditions, when a solution of dry acetonitrile is electrolyzed at a Carbon rod as cathode and a magnesium plate as anode in undivided cell. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Authors
Sbei N. 1 , Titov A.A. 1 , Markova E.B. 2 , Elinson M.N.3 , Voskressensky L.G. 1
Journal
ChemistrySelect
Publisher
Wiley-Blackwell
Number of issue
15
Language
English
Pages
4493-4495
Status
Published
Link
External link
DOI
10.1002/slct.202000869
Volume
5
Year
2020
Organizations
  • 1 Research Center: Molecular Design and Synthesis of Innovative Compounds for Medicine, Peoples' Friendship University of Russia(RUDN University), Moscow, Miklukho-Maklaya st https://twitter.com/UniversityRudn, 117198, Russian Federation
  • 2 Physical and Colloidal Chemistry Department, RUDN University Peoples' Friendship University of Russia (RUDN University), Moscow, Miklukho-Maklaya st, 117198, Russian Federation
  • 3 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect, 47, Moscow, Moscow, Russian Federation
Keywords
1,2,3,4-tetrahydroisoquinoline-1-carbonitrile; cathodic reduction; cyanide anion; dihydroisoquinolin-2-ium iodide; electrochemical synthesis
Date of creation
02.11.2020
Date of change
02.11.2020
Short link
https://repository.rudn.ru/en/records/article/record/64826/
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