Antiviral, antibacterial, antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-triaza-7-phoshaadamantane and pyromellitic acid

The present study reports the synthesis, characterization, and crystal structure of a novel bioactive metal-organic framework, [Ag4(μ-PTA)2(μ3-PTA)2(μ4-pma)(H2O)2]nμ6nH2O (bioMOF 1), which was assembled from silver(I) oxide, 1,3,5-triaza-7-phosphaadamantane (PTA), and pyromellitic acid (H4pma). This product was isolated as a stable microcrystalline solid and characterized by standard methods, including elemental analysis, 1H and 31P{1H} NMR and FTIR spectroscopy, and single crystal X-ray diffraction. The crystal structure of 1 disclosed a very complex ribbon-pillared 3D metal-organic framework driven by three different types of bridging ligands (μ-PTA, μ3-PTA, and μ4-pma4-). Various bioactivity characteristics of bioMOF 1 were investigated, revealing that this compound acts as a potent antimicrobial against pathogenic strains of standard Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria, as well as a yeast (Candida albicans). Further, 1 showed significant antiviral activity against human adenovirus 36 (HAdV-36). Finally, bioMOF 1 revealed high cytotoxicity toward an abnormal epithelioid cervix carcinoma (HeLa) cell line with low toxicity toward a normal human dermal fibroblast (NHDF) cell line. This study not only broadens the family of PTA-based coordination polymers but also highlights their promising multifaceted bioactivity. © 2020 by the authors.

Authors
Jaros S.W.1 , Król J.2 , Bazanów B.2 , Poradowski D.3 , Chrószcz A.3 , Nesterov D.S. 4, 5 , Kirillov A.M. 4, 5 , Smoleński P.1
Journal
Publisher
MDPI AG
Number of issue
9
Language
English
Status
Published
Number
2119
Volume
25
Year
2020
Organizations
  • 1 Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, Wrocław, 50-383, Poland
  • 2 Department of Veterinary Microbiology, Wrocław University of Environmental and Life Sciences, Norwida 31, Wrocław, 50-375, Poland
  • 3 Department of Animal Physiology and Biostructure, Wrocław University of Environmental and Life Sciences, Kozuchowska 1, Wrocław, 51-631, Poland
  • 4 Centro de Química Estrutural, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon, 1049-001, Portugal
  • 5 Research Institute of Chemistry, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya st., Moscow, 117198, Russian Federation
Keywords
1,3,5-triaza-7-phosphaadamantane; Antimicrobial activity; Antiviral activity; Coordination polymers; Cytotoxic activity; Metal-organic frameworks; Pyromellitic acid; Silver complexes
Date of creation
02.11.2020
Date of change
02.11.2020
Short link
https://repository.rudn.ru/en/records/article/record/64807/
Share

Other records