Comparative Analysis of the Paracrine Action of Neuronal and Glial Progenitor Cells Derived from Induced Human Pluripotent Stem Cells

We performed comparative analysis of paracrine activity of neuronal and glial progenitors derived from induced pluripotent stem cells under conditions of hypoxia modeled by addition of cobalt dichloride. Neuronal and glial progenitors produced neuroprotective and neurotrophic effects on SHSY-5Y neuroblastoma cells in co-culture during the post-hypoxic recovery and reduced the number of apoptotic and necrotic cells. Moreover, they produced a neurotrophic effect and promote the formation and growth of neurites in neuroblastoma cells. The paracrine effect of glial progenitors was more pronounced, which can be explained by more intensive expression and secretion of neurotrophic factors in these cells. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Authors
Salikhova D.I.1, 2 , Leonov G.E.1 , Bukharova T.B.1 , Bulatenko N.V.1 , Efremovа A.S.1 , Makhnach O.V.1 , Makarov A.V. 2 , Fatkhudinov T.H. 2, 3 , Goldshtein D.V. 1, 3
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
1
Language
English
Pages
176-181
Status
Published
Volume
169
Year
2020
Organizations
  • 1 N. P. Bochkov Research Center for Medical Genetics, Moscow, Russian Federation
  • 2 Research Institute of Human Morphology, Moscow, Russian Federation
  • 3 Peoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation
Keywords
cell therapy; glial progenitors; induced pluripotent stem cells; neuronal progenitors; paracrine effect
Date of creation
02.11.2020
Date of change
02.11.2020
Short link
https://repository.rudn.ru/en/records/article/record/64785/
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