Environmentally-induced alternative oncogenesis: EROS arrows

The cause of the oncological diseases in children and the specific spectrum of this pathology, with hemangiomas prevailing among benign tumors (BT), and leukemia, lymphomas, and neural tissue tumors among malignant neoplasms (MN), remains unknown. The authors studied the similarities and differences of the connections between environmental factors, benign tumors and MN, as well as the relations between BT and MN. The causality of the so-called "sporadic" fluctuations in the incidence of neoplasms and their relations with environmental factors were revealed. A hypothesis of environmentally-induced alternative oncogenesis is suggested. According to the hypothesis, fetal hemoglobin enhances environmentally-related oxidative stress (EROS), leading to epigenomic regulation disorder of SEMA 7A and MICAL family proteins in the endothelium, axon growth cone, and hematopoietic stem cells. © The Authors, published by EDP Sciences, 2020.

Conference proceedings
Publisher
EDP Sciences
Language
English
Status
Published
Number
04006
Volume
169
Year
2020
Organizations
  • 1 Far Eastern State Medical University, Khabarovsk, Russian Federation
  • 2 Peoples' Friendship University of Russia (RUDN University), Faculty of Ecology, 6 MiklukhoMaklaya St, Moscow, 117198, Russian Federation
Keywords
Ecology; Pathology; Planning; Stem cells; Sustainable development; Tumors; Axon growth; Benign tumor; Environmental factors; Hematopoietic stem cells; Neural tissue; Oncogenesis; Oncological disease; Environmental management
Date of creation
02.11.2020
Date of change
02.11.2020
Short link
https://repository.rudn.ru/en/records/article/record/64734/
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