Pyridine-Enabled C-N Bond Activation for the Rapid Construction of Amides and 4-Pyridylglyoxamides by Cooperative Palladium/Copper Catalysis

A pyridine-enabled C-N bond activation of peptidomimetics employing cooperative palladium/copper catalysis in water is developed. Diverse amides and 4-pyridylglyoxamides are simultaneously synthesized through two steps from commercially available materials in a rapid, environmentally friendly, and high atom-economical manner. Copyright © 2020 American Chemical Society.

Authors
Song L.1 , Claessen S.1 , Van Der Eycken E.V.
Journal
Journal of Organic Chemistry
Number of issue
12
Language
English
Pages
8045-8054
Status
Published
Link
External link
DOI
10.1021/acs.joc.0c00845
Volume
85
Year
2020
Organizations
  • 1 Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, Ku Leuven, Celestijnenlaan 200F, Leuven, 3001, Belgium
  • 2 Peoples' Friendship University of Russia, Rudn University, Miklukho-Maklaya street 6, Moscow, 117198, Russian Federation
Keywords
Amides; Catalysis; Palladium; Pyridine; Bond activation; Catalysis in water; Peptidomimetics; Rapid construction; Chemical activation; 4 pyridylglyoxamide; amide; copper; imine; oxidizing agent; palladium; peptidomimetic agent; pyridine; solvent; unclassified drug; water; Article; catalysis; chemical bond; chemical reaction; chemical structure; deprotonation; electron transport; oxidation; proton nuclear magnetic resonance; synthesis
Date of creation
02.11.2020
Date of change
02.11.2020
Short link
https://repository.rudn.ru/en/records/article/record/64645/
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