Izvestiya Mathematics.
Institute of Physics Publishing.
Vol. 84.
2020.
P. 659-682
New Matrix Compounds for the Detection of Carboxyl-Containing Nonsteroidal Anti-Inflammatory Drugs by MALDI Mass Spectrometry
Abstract: The possibility of employing the method of mass spectrometry with matrix-assisted laser desorption/ionization (MALDI) for the rapid detection of carboxyl-containing nonsteroidal anti-inflammatory drugs has been studied. Comparison of the results obtained using the previously described and newly proposed as matrix compounds 4-(dimethylamino)benzaldehyde and N,N-dimethyl-p-phenylenediamine, showed that the latter provide the registration of mass spectra containing intense peaks of deprotonated molecules of all drugs used in the work. Comparison of the time required for their detection by various mass spectrometric methods has shown that MALDI mass spectrometry provides the highest performance in streaming analysis. © 2020, Pleiades Publishing, Ltd.
Authors
Publisher
Pleiades Publishing
Number of issue
8
Language
English
Pages
1244-1253
Status
Published
Link
Volume
93
Year
2020
Organizations
- 1 Scientific Centre for Expert Evaluation of Medicinal Products, Moscow, 127051, Russian Federation
- 2 Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, 119991, Russian Federation
- 3 Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
Keywords
authenticity; carboxyl-containing compounds; deprotonating matrices; detection; MALDI mass spectrometry; negative ions; nonsteroidal anti-inflammatory drugs; quality control
Date of creation
02.11.2020
Date of change
02.11.2020
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Russian Journal of Numerical Analysis and Mathematical Modelling.
Walter de Gruyter GmbH.
Vol. 35.
2020.
P. 203-213