Glutathione Synthesis in Cancer Cells

Abstract: Tripeptide GSH is associated not only with the control and maintenance of redox cell homeostasis, but also with the processes of detoxification, proliferation, cell differentiation, and regulation of cell death. Disruptions in GSH synthesis and changes in the GSH/GSSG ratio are common for many pathological conditions, including malignant neoplasms. Numerous data indicate the importance of GSH and the GSH/GSSG ratio in the regulation of tumor cell viability, in the initiation of tumor development, progression, and drug resistance. However, control of the mechanism of GSH synthesis in malignant tumors remains poorly understood. This review discusses the features of GSH synthesis and its regulation in tumor cells. The role of GSH in the mechanisms of apoptosis, necroptosis, ferroptosis, and autophagy is considered. © 2020, Pleiades Publishing, Ltd.

Number of issue
8
Language
English
Pages
895-907
Status
Published
Volume
85
Year
2020
Organizations
  • 1 Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
Keywords
apoptosis; autophagy; de novo GSH synthesis; ferroptosis; microRNA; necroptosis
Date of creation
02.11.2020
Date of change
02.11.2020
Short link
https://repository.rudn.ru/en/records/article/record/64485/
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