Hydrogen-free reductive amination using iron pentacarbonyl as a reducing agent

We developed solvent-free reductive amination without an external hydrogen source using iron pentacarbonyl as a reducing agent. Neither a catalyst nor any other additives were employed. Various types of substrates are suitable for the reaction, including those with low reactivity, e.g. benzophenone. Among others, the protocol tolerates bromo-, cyano-, benzyloxy-, pyrimidyl and styryl moieties. © 2017 The Royal Society of Chemistry.

Authors
Afanasyev O.I.1 , Usanov D.L.2 , Chusov D. 1, 3
Journal
Organic and Biomolecular Chemistry
Publisher
Royal Society of Chemistry
Number of issue
48
Language
English
Pages
10164-10166
Status
Published
Link
External link
DOI
10.1039/c7ob02795h
Volume
15
Year
2017
Organizations
  • 1 A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St 28, Moscow, 119991, Russian Federation
  • 2 Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, United States
  • 3 Faculty of Science, RUDN University, 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation
Keywords
Chemistry; Positive ions; Hydrogen sources; Iron pentacarbonyls; Reductive amination; Solvent free; Amines
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/6142/
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