Direct C-2 acylation of indoles with toluene derivatives via Pd(II)-catalyzed C-H activation

A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert-butylhydroperoxide (TBHP) as oxidant and pivalic acid as additive, providing moderate to good yields. © 2017 The Royal Society of Chemistry.

Authors
Zhao Y.3 , Sharma U.K.1 , Schröder F.1 , Sharma N.1 , Song G.3 , Van Der Eycken E.V.
Journal
RSC Advances
Number of issue
52
Language
English
Pages
32559-32563
Status
Published
Link
External link
DOI
10.1039/c7ra06004a
Volume
7
Year
2017
Organizations
  • 1 Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, KU Leuven, Celestijnenlaan 200F, Leuven, B-3001, Belgium
  • 2 Peoples Friendship University of Russia, RUDN University, 6 Miklukho-Maklaya street, Moscow, 117198, Russian Federation
  • 3 Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai, 200237, China
Keywords
Activation analysis; Acylation; Catalysis; Toluene; Acyl source; C-h activation; Pivalic acid; Tert-butylhydroperoxide; Palladium compounds
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/6117/
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