Central Asia and the Caucasus.
CA and CC Press AB.
Vol. 18.
2017.
P. 43-51
Copper-Catalyzed Multicomponent Reactions: Synthesis of Fused 1,2,3-Triazolo-1,3,6-triazonines
We describe our results on the synthesis of fused 1,2,3-triazolo-1,3,6-triazonines through a copper-catalyzed multicomponent reaction. The products were obtained in moderate to excellent yields by the reaction of 2-azidobenzaldehydes, substituted diaminobenzenes and a range of terminal alkynes in the presence of a catalytic amount of copper iodide, with Et3N as base, in DMSO at 100 °C. This method proved to be efficient for the combinatorial synthesis of new medium-sized N-heterocyclic rings with potential applications in biological studies. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Authors
Peringer F.1
,
Do Nascimento J.E.R. ,
Abib P.B.1
,
Barcellos T.2
,
Van Der Eycken E.V. ,
Perin G.1
,
Jacob R.G.1
,
Alves D.1
Number of issue
18
Language
English
Pages
2579-2586
Status
Published
Link
Volume
2017
Year
2017
Organizations
- 1 LASOL-CCQFA, Universidade Federal de Pelotas - UFPel, P. O. Box 354, Pelotas, RS 96010-900, Brazil
- 2 Laboratory of Biotechnology of Natural and Synthetic Products, Universidade de Caxias do Sul, Caxias do Sul, RS, Brazil
- 3 Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, Leuven, 3001, Belgium
- 4 Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya street, Moscow, 117198, Russian Federation
Keywords
Click chemistry; Copper; Fused-ring systems; Heterocycles; Medium-ring compounds; Multicomponent reactions
Date of creation
19.10.2018
Date of change
19.10.2018
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13th International MEDCOAST Congress on Coastal and Marine Sciences, Engineering, Management and Conservation, MEDCOAST 2017.
Mediterranean Coastal Foundation.
Vol. 2.
2017.
P. 795-804