Synthesis of Functionalized Partially Hydrogenated Quinolines by a Stork Reaction - Intramolecular Transamination - Alkylation Tandem Protocol

A Stork reaction — intramolecular transamination — alkylation tandem protocol was used to synthesize functionalized partially hydrogenated quinolines. The molecular and crystal structures of 5-(4-methoxyphenyl)-8,8-dimethyl-6-oxo-2,5,6,7,8,9-hexahydro-1H-thiazolo[3,2-a]quinoline-4-carbonitrile, 9-allyl-3-amino-7,7-dimethyl-5-oxo-4-phenyl-4,5,6,7,8,9-hexahydrothieno[2,3-b]quinoline-2-carbonitrile, and 3-amino-4-(2,5-dimethoxyphenyl)-N-phenyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide were studied by X-ray diffraction analysis.