Laser-triggered drug release from polymeric 3-D micro-structured films via optical fibers

Photosensitive polymeric three-dimensional microstructured film (PTMF) is a new type of patterned polymeric films functionalized with an array of sealed hollow 3D containers. The microstructured system with enclosed chemicals provides a tool for the even distribution of biologically active substances on a given surface that can be deposited on medical implants or used as a cells substrate. In this work, we proposed a way for photothermally activating and releasing encapsulated substances at picogram amounts from the PTMF surface in different environments using laser radiation delivered with a multimode optical fiber. The photosensitive PTMFs were prepared by the layer-by-layer (LbL) assembly from alternatively charged polyelectrolytes followed by covering with a layer of hydrophobic polylactic acid (PLA) and a layer of gold nanoparticles (AuNPs). Moreover, the typical photothermal cargo release amounts were determined on the surface of the PTMF for a range of laser powers delivered to films placed in the air, deionized (DI) water, and 1% agarose gel. The agarose gel was used as a soft tissue model for developing a technique for the laser activation of PTMFs deep in tissues using optical waveguides. The number of PTMF chambers activated by a near-infrared (NIR) laser beam was evaluated as the function of optical parameters. © 2020 Elsevier B.V.

Kurochkin M.A.1, 7 , Sindeeva O.A. 2, 11 , Brodovskaya E.P.6 , Gai M.3, 4 , Frueh J.7, 8 , Su L.3 , Sapelkin A.5 , Tuchin V.V.9, 10, 12 , Sukhorukov G.B. 1, 11, 3, 13
Elsevier Ltd
  • 1 Skolkovo Institute of Science and Technology, 3 Nobelya Str., Moscow, 143025, Russian Federation
  • 2 Remote Controlled Theranostic Systems Lab, Department of Nanotechnology, Educational and Research Institute of Nanostructures and Biosystems, Saratov State University, Saratov, 410012, Russian Federation
  • 3 School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, United Kingdom
  • 4 Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz, D-55128, Germany
  • 5 School of Physics and Astronomy, Queen Mary University of London, London, E1 4NS, United Kingdom
  • 6 National Research Mordovia State University, 68 Bolshevistskaya Str., Saransk, Republic of Mordovia 430005, Russian Federation
  • 7 Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education Micro/Nanotechnology Research Centre, Harbin Institute of Technology, 2 Yikuang Street B1, Harbin, 150080, China
  • 8 Institute of Environmental Engineering, Eidgenoessische Technische Hochschule Zurich, Stefano-Franscini-Platz 3, Zurich, 8093, Switzerland
  • 9 Interdisciplinary Laboratory of Biophotonics, Tomsk State University, 36 Lenin's av., Tomsk, 634050, Russian Federation
  • 10 Laboratory of Laser Diagnostics of Technical and Living Systems, Institute of Precision Mechanics and Control of the Russian Academy of Science, 24 Rabochaya str., Saratov, 410028, Russian Federation
  • 11 Surface Engineering Lab, Innovative Engineering Technologies Institute, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
  • 12 Research-Educational Institute of Optics and Biophotonics, Saratov State University, 83 Astrakhanskaya street, Saratov, 410012, Russian Federation
  • 13 I. M. Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation
Chamber array; Controlled drug delivery; Infrared laser; Microstructured film; Optical fiber; Polyelectrolyte multilayer
Date of creation
Date of change
Short link

Other records