Synthesis of new [γ-(Aryl)pyridino]dibenzo-27,28-diazacrownophanes containing two pyridine rings

In continuation of developing new cytotoxic compounds, six azacrownophanes containing both 2,4,6-triarylpyri-dine and 2,6-bis(phenoxymethyl)pyridine moieties were synthesized successfully by one-step domino-condensation of podand 2,6-bis[(2-acetophenyl)oxymethyl]pyridine, arylaldehydes and ammonium acetate according to the conditions of Hantzsch reactions. The compounds 5a-c were selected for cytotoxicity evaluations against human cell lines (HepG2, Lu1, RD, FL and MCF-7). Compound 5b showing the highest cytotoxicity is interesting for the development of promising anticancer drugs. © ISUCT Publishing.

Authors
Anh L.T. 1 , Huyen N.T.T.1 , Tam P.T.T.1, 2 , Dat N.T.1 , Hieu T.H. 3 , Van T.T.T.1 , Hanh L.T.M.1 , Soldatenkov A.T. 3 , Wodajo A.T. 4
Editors
-
Publisher
-
Number of issue
3
Language
English
Pages
307-311
Status
Published
Department
-
Number
-
Volume
12
Year
2019
Organizations
  • 1 Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, 100000, Viet Nam
  • 2 Faculty of Pharmacy, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen City, 250000, Viet Nam
  • 3 Peoples’ Friendship, University of Russia, Moscow, 117198, Russian Federation
  • 4 College of Natural and Computational Sciences, University of Gondar, Gondar, 196, Ethiopia
Keywords
Arylpyridine; Azacrownophane; Cytotoxicity; Hantzsch reaction
Date of creation
10.02.2020
Date of change
10.02.2020
Short link
https://repository.rudn.ru/en/records/article/record/56474/