The article on the materials of the Yenisei province analyzes the model of interaction between the executive authorities, city government and public organizations in the fight against epidemics in the late XIX - early XX centuries. The main directions of anti-epidemic activities in the Yenisei Siberia are characterized, the legal and financial conditions for their implementation are identified, and their effectiveness is assessed. The conclusion is formulated that the state policy in the field of health care, not taking into account the regional peculiarities of Siberia, has created a number of problems in the process of implementing sanitary epidemiological measures. In the conditions of the formation of the state concept of combating epidemics in the second half of the XIX century, the initiative activity of public organizations in the region, supported by city self-government bodies, became the basis for the formation of an anti-epidemic system in the province. Copyright © 2019 by Academic Publishing House Researcher s.r.o.