Phenotypical and Functional Polymorphism of Liver Resident Macrophages

Liver diseases are one of the main causes of mortality. In this regard, the development of new ways of reparative processes stimulation is relevant. Macrophages play a leading role in the regulation of liver homeostasis in physiological conditions and in pathology. In this regard, the development of new liver treatment methods is impossible without taking into account this cell population. Resident macrophages of the liver, Kupffer cells, represent a unique cell population, first of all, due to their development. Most of the liver macrophages belong to the self-sustaining macrophage cell population, whose origin is not bone marrow. In addition, Kupffer cells are involved in such processes as regulation of hepatocyte proliferation and apoptosis, remodeling of the intercellular matrix, lipid metabolism, protective function, etc. Such a broad spectrum of liver macrophage functions indicates their high functional plasticity. The review summarizes recent data on the development, phenotypic and functional plasticity, and participation in the reparative processes of liver macrophages: resident macrophages (Kupffer cells) and bone marrow-derived macrophages.

Authors
Elchaninov A.V. 1, 2 , Fatkhudinov T.K. 3, 4 , Vishnyakova P.A.1 , Lokhonina A.V. 1, 3 , Sukhikh G.T.1
Number of issue
9
Language
English
Status
Published
Number
1032
Volume
8
Year
2019
Organizations
  • 1 Minist Healthcare Russian Federat, Natl Med Res Ctr Obstet Gynecol & Perinatol, 4 Oparina St, Moscow 117997, Russia
  • 2 Pirogov Russian Natl Res Med Univ, Minist Healthcare Russian Federat, Histol Embryol & Cytol Dept, 1 Ostrovitianov St, Moscow 117997, Russia
  • 3 Peoples Friendship Univ Russia, Histol Embryol & Cytol Dept, 6 Miklukho Maklaya St, Moscow 117198, Russia
  • 4 Sci Res Inst Human Morphol, 3 Tsurupa St, Moscow 117418, Russia
Keywords
monocytes; macrophages; Kupffer cells
Date of creation
24.12.2019
Date of change
24.12.2019
Short link
https://repository.rudn.ru/en/records/article/record/55663/
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