The article describes the indicators of secondary immune deficiency in pregnant cows during the cow drying off. Morphological, biochemical, and immunological blood parameters are displayed. Clinical manifestation of calf hypotrophy syndrome during the neonatal period is studied. The experience of using Aminoseleton for pregnant cows during the drying off is describes. Evaluation of the biological effect on the organism of cows of a new tissue biostimulator was carried out on 22 cows with secondary immunodeficiency 30-45 days before calving, formed on the principle of paired analogues in two groups. Aminoseleton was used subcutaneously five times every 72 hours at a dose of 40 ml. The positive effect of immunomodulator Aminoseleton on metabolic status and the overall non-specific resistance indicators during the cow drying off was revealed. According to the results hypotrophic calves were born with a deficiency of body weight and a non-proportional physique. Tendency to centralize circulation, hypovolemia, hyperdynamic reaction with infarction, pulmonary hypertension with, spastic condition precapillary arterioles, disturbance of microcirculation in microvessels in newborn hypotrophic calves was observed. In perinatal hypotrophy in calves, inhibition of cellular immunity was noted predominantly against the background of an increased activity of oxidative metabolism in neutrophils. The results of our research indicate a violation of the structure and links of non-specific cellular and humoral resistance in calves with perinatal hypotrophy. As a result, a direct correlation between the level of non-specific resistance of the mother’s organism, and the state of health condition of the newborns is established. © 2019 Popova et al.