Incomplete form of kawasaki disease with coronary and peripheral artery aneurysms and immunoglobulin-resistant course

Mucocutaneous lymphonodular syndrome (Kawasaki disease-KD) is a systemic vasculitis of middle and small arteries, clinically manifested by fever, changes in the mucous membranes, skin, lymphadenopathy. Lesion of cardiovascular system occurs in approximately 50% of patients; in 25-40% without treatment, artery aneurysms are formed. The incidence of peripheral arteries lesion is 2%. The main method of treatment is intravenous immunoglobulin (IVIG) at a dose of 2 g/kg and acetylsalicylic acid. However, 10-30% of patients can have resistance to standard therapy. In this case, the use of inhibitors of tumor necrosis factor alpha is recommended. The article presents clinical observation of a child with an incomplete form of KD, giant coronary and peripheral artery aneurysms, resistance to IVIG therapy and a complication in the form of a thrombus in the left coronary artery. © 2018, Pediatria Ltd. All rights reserved.

Authors
Novikova Y.Y. 1, 2 , Kantemirova M.G. 1, 2 , Kurbanova S. 1, 2 , Glazirina A.A. 1, 2 , Korovina O.A. 1, 2 , Andreev P.S. 1 , Ovsyannikov D.Y. 1, 2 , Valieva S.I.2 , Petryatkina E.E. 1, 2
Number of issue
3
Language
Russian
Pages
284-290
Status
Published
Volume
98
Year
2019
Organizations
  • 1 Peoples’ Friendship University of Russia, Moscow, Russian Federation
  • 2 Morozov Children’s City Clinical Hospital, Moscow, Russian Federation
Keywords
Children; Coronary and peripheral artery aneurysms; Incomplete form; Kawasaki disease; Resistance to intravenous immunoglobulin therapy
Date of creation
24.12.2019
Date of change
24.12.2019
Short link
https://repository.rudn.ru/en/records/article/record/55210/