Synthesis and bioactivity of novel (γ-piperidono)dibenzo-33-aza-14-crown-3 ethers

[Figure not available: see fulltext.] Three-component reaction of polyether-linked bisnaphthaldehyde, ketone derivative, and ammonium acetate afforded seven new azacrown ethers containing γ-piperidone fragment with moderate yields. Most of the compounds were tested for their bioactivity. (3,5-Diethylpiperidono)azacrown ether showed significant cytotoxicity against Hep-G2, Lu1, RD, and MCF-7 cell lines. In addition, three of the synthesized azacrown ethers showed positive effect in antimicrobial test against Aspergillus niger. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Authors
Dao T.N. 1 , Truong H.H. 2 , Luu V.B.1 , Soldatenkov A.T. 2 , Kolyadina N.M. 2 , Kulakova A.N. 3 , Khrustalev V.N. 2, 3 , Wodajo A.T. 4 , Nguyen H.Q.1 , Van Tran T.T. , Le T.A. 1
Journal
Chemistry of Heterocyclic Compounds
Publisher
Латвийский институт органического синтеза Латвийской академии наук / Springer New York Consultants Bureau
Number of issue
7
Language
English
Pages
654-659
Status
Published
Link
External link
DOI
10.1007/s10593-019-02512-7
Volume
55
Year
2019
Organizations
  • 1 Faculty of Chemistry, VNU University of Science, 19 Le Thanh Tong, Hoan Kiem, Hanoi, 100000, Viet Nam
  • 2 RUDN University, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
  • 3 National Research Center “Kurchatov Institute”, 1 Akademika Kurchatova Sq., Moscow, 123182, Russian Federation
  • 4 College of Natural and Computational Sciences, Department of Chemistry, University of Gondar, Gondar, P. O. Box 196, Ethiopia
Keywords
2,2'-[oxybis(ethane-2,1-diyloxy)]dinaphthalene-1-carbaldehyde; azacrown ether; cytotoxicity; Petrenko–Kritschenko reaction; X-ray diffraction study
Date of creation
24.12.2019
Date of change
24.12.2019
Short link
https://repository.rudn.ru/en/records/article/record/55152/
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