Biomedical Engineering.
Springer New York LLC.
Vol. 53.
2019.
P. 87-91
Synthesis and bioactivity of novel (γ-piperidono)dibenzo-33-aza-14-crown-3 ethers
[Figure not available: see fulltext.] Three-component reaction of polyether-linked bisnaphthaldehyde, ketone derivative, and ammonium acetate afforded seven new azacrown ethers containing γ-piperidone fragment with moderate yields. Most of the compounds were tested for their bioactivity. (3,5-Diethylpiperidono)azacrown ether showed significant cytotoxicity against Hep-G2, Lu1, RD, and MCF-7 cell lines. In addition, three of the synthesized azacrown ethers showed positive effect in antimicrobial test against Aspergillus niger. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Authors
Dao T.N.
1
,
Truong H.H.
2
,
Luu V.B.1
,
Soldatenkov A.T.
2
,
Kolyadina N.M.
2
,
Kulakova A.N.
3
,
Khrustalev V.N.
2,
3
,
Wodajo A.T.
4
,
Nguyen H.Q.1
,
Van Tran T.T. ,
Le T.A.
1
Publisher
Латвийский институт органического синтеза Латвийской академии наук / Springer New York Consultants Bureau
Number of issue
7
Language
English
Pages
654-659
Status
Published
Link
Volume
55
Year
2019
Organizations
- 1 Faculty of Chemistry, VNU University of Science, 19 Le Thanh Tong, Hoan Kiem, Hanoi, 100000, Viet Nam
- 2 RUDN University, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
- 3 National Research Center “Kurchatov Institute”, 1 Akademika Kurchatova Sq., Moscow, 123182, Russian Federation
- 4 College of Natural and Computational Sciences, Department of Chemistry, University of Gondar, Gondar, P. O. Box 196, Ethiopia
Keywords
2,2'-[oxybis(ethane-2,1-diyloxy)]dinaphthalene-1-carbaldehyde; azacrown ether; cytotoxicity; Petrenko–Kritschenko reaction; X-ray diffraction study
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Biomedical Engineering.
Springer New York LLC.
Vol. 53.
2019.
P. 108-111