Association of DNMT3B and DNMN3L Gene Polymorphisms with Early Pregnancy Loss

A total of 100 women with early pregnancy loss were recruited and further classified into two subgroups: sporadic pregnancy loss and recurrent pregnancy loss; each subgroup consisted of 50 women. The control group included 56 women with normal pregnancies. Genotyping was performed by PCR with restriction fragment length polymorphism analysis. A statistically significant increase in the frequencies of TT genotype and T allele for DNMT3B rs2424913 polymorphism was found in the total patient group and in both patient subgroups in comparison with the control. Moreover, homozygous TT genotype was associated with increased risk of early pregnancy loss (both sporadic and recurrent). DNMT3B rs2424913 gene polymorphism in women can be used a marker of predisposition to early pregnancy loss and recurrent pregnancy loss. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Authors
Azova M.M. 1 , Ahmed A.A. 1 , Ait Aissa A. , Blagonravov M.L. 2
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
4
Language
English
Pages
475-478
Status
Published
Volume
167
Year
2019
Organizations
  • 1 Department of Biology and General Genetics, Moscow, Russian Federation
  • 2 V. A. Frolov Department of General Pathology and Pathophysiology, Medical Institute, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation
Keywords
DNA methyltransferases; early pregnancy loss; single nucleotide polymorphisms
Date of creation
24.12.2019
Date of change
24.12.2019
Short link
https://repository.rudn.ru/en/records/article/record/55113/
Share

Other records