Antiproliferative activity of Pt(IV) complexes with lonidamine and bexarotene ligands attached via succinate-ethylenediamine linker

We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with lonidamine and bexarotene ligand tethered to Pt-center via a succinate-ethylenediamine linker. The in vitro results for a series of complexes with cisplatin, dichloride(ethane-1,2-diamine)platinum(II), or oxaliplatin core indicate that the addition to the structure lonidamine or bexarotene moiety can confer activity or selectivity of Pt(IV) complexes. © 2019 Elsevier B.V.

Authors
Okulova Y.N.1 , Zenin I.V.1 , Shutkov I.A.1 , Kirsanov K.I. 2, 3 , Kovaleva O.N.4 , Lesovaya E.A.2, 5 , Fetisov T.I.2 , Milaeva E.R.1 , Nazarov A.A. 1
Journal
Inorganica Chimica Acta
Language
English
Status
Published
Link
External link
DOI
10.1016/j.ica.2019.119010
Number
119010
Volume
495
Year
2019
Organizations
  • 1 Lomonosov Moscow State University, Department of Medicinal Chemistry and Fine Organic Synthesis, Leninskie Gory 1/3, Moscow, 119991, Russian Federation
  • 2 N. N. Blokhin National Medical Research Centre of Oncology, 24 Kashirskoye Shosse, Moscow, 115478, Russian Federation
  • 3 RUDN University, 6 Miklukho-Maklaya, Moscow, 117198, Russian Federation
  • 4 I.M.Sechenov First Moscow State Medical University, Moscow, Russian Federation
  • 5 Ryazan State Medical University, 9 Visokovoltnaya, Ryazan, 390026, Russian Federation
Date of creation
24.12.2019
Date of change
24.12.2019
Short link
https://repository.rudn.ru/en/records/article/record/55082/
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