Mitochondrial calcium uniporter structure and function in different types of muscle tissues in health and disease

Calcium ions (Ca2+) influx to mitochondrial matrix is crucial for the life of a cell. Mitochondrial calcium uniporter (mtCU) is a protein complex which consists of the pore-forming subunit (MCU) and several regulatory subunits. MtCU is the main contributor to inward Ca2+ currents through the inner mitochondrial membrane. Extensive investigations of mtCU involvement into normal and pathological molecular pathways started from the moment of discovery of its molecular components. A crucial role of mtCU in the control of these pathways is now recognized in both health and disease. In particular, impairments of mtCU function have been demonstrated for cardiovascular and skeletal muscle-associated pathologies. This review summarizes the current state of knowledge on mtCU structure, regulation, and function in different types of muscle tissues in health and disease. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Authors
Tarasova N.V.1 , Vishnyakova P.A.2 , Logashina Y.A.1, 3 , Elchaninov A.V. 2, 4, 5
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Number of issue
19
Language
English
Status
Published
Link
External link
DOI
10.3390/ijms20194823
Number
4823
Volume
20
Year
2019
Organizations
  • 1 Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Trubetskaya str. 8, bld. 2, Moscow, 119991, Russian Federation
  • 2 National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow, 117997, Russian Federation
  • 3 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street 16/10, Moscow, 117997, Russian Federation
  • 4 Scientific Research Institute of Human Morphology, 3 Tsurupa Street, Moscow, 117418, Russian Federation
  • 5 Peoples’ Friendship University of Russia, 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation
Keywords
Calcium; Calcium homeostasis; Calcium signaling; Mitochondrial calcium uniporter; Myocardium; Regulatory pathways; Skeletal muscle; Smooth muscle
Date of creation
24.12.2019
Date of change
24.12.2019
Short link
https://repository.rudn.ru/en/records/article/record/55006/
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