Diversification of Peptidomimetics and Oligopeptides through Microwave-Assisted Rhodium(III)-Catalyzed Intramolecular Annulation

A chemoselective rhodium(III)-catalyzed cascade annulation for the construction of the indolizinone and quinolizinone scaffolds is developed. Diversification of peptidomimetics and oligopeptides is achieved in a rapid and step-economical manner through the combination of Ugi reaction and microwave-assisted rhodium(III)-catalyzed intramolecular annulation via C(sp2)-H activation without installing a directing group. (Figure presented.). © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Authors
Song L.1 , Tian G.1 , Blanpain A.1 , Van Meervelt L. , Van Der Eycken E.V.
Journal
Advanced Synthesis and Catalysis
Publisher
Wiley-VCH Verlag
Number of issue
19
Language
English
Pages
4442-4447
Status
Published
Link
External link
DOI
10.1002/adsc.201900550
Volume
361
Year
2019
Organizations
  • 1 Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven Celestijnenlaan 200F, Leuven, 3001, Belgium
  • 2 Biomolecular Architecture, Department of Chemistry, KU Leuven Celestijnenlaan 200F, Leuven, 3001, Belgium
  • 3 Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, Moscow, Russian Federation
Keywords
Annulation; C−H Activation; Peptide; Peptidomimetic; Rhodium
Date of creation
24.12.2019
Date of change
24.12.2019
Short link
https://repository.rudn.ru/en/records/article/record/54967/
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