Comparison of Quantitative Analytical Techniques for Dabigatran in Blood Plasma of Humans with Knee Replacements

Two different literature methods were used to compare the experimental efficacy and accuracy of dabigatran assays in blood of 30 patients with knee replacements. Blood plasma was collected from patients who underwent anticoagulant therapy and were administered the medicine at a dose of 220 mg. Residual and peak dabigatran concentrations were determined by HPLC-MS and HPLC-MS/MS. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Authors
Kozlov A.V. 1 , Smirnov V.V. 1 , Sychev D.A.2 , Bochkov P.O. 3 , Chistyakov V.V. 4 , Stepanova E.S. 4 , Makarenkova L.M. 4
Journal
Pharmaceutical Chemistry Journal
Number of issue
8
Language
English
Pages
771-774
Status
Published
Link
External link
DOI
10.1007/s11094-019-02077-x
Volume
53
Year
2019
Organizations
  • 1 I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russian Federation
  • 2 Russian Medical Academy of Continuous Professional Education, Ministry of Health of the RF, Moscow, 125993, Russian Federation
  • 3 V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, 125315, Russian Federation
  • 4 Research and Education Center, Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
Keywords
anticoagulant; dabigatran; HPLC; mass-spectroscopy; pharmacokinetics
Date of creation
24.12.2019
Date of change
24.12.2019
Short link
https://repository.rudn.ru/en/records/article/record/54930/
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