Role of MicroRNAs in the Regulation of Redox-Dependent Processes

Cellular redox homeostasis involves a combination of redox processes and corresponding regulatory systems and represents an important factor ensuring cell viability. Redox-dependent regulation of cellular processes is a multi-level system including not only proteins and enzyme complexes, but also non-coding RNAs, among which an important role belongs to microRNAs. The review focuses on the involvement of miRNAs in the redox-dependent regulation of both ROS (reactive oxygen species)-generating enzymes and antioxidant enzymes with special emphasis on the effects of miRNAs on redox-dependent processes in tumor cells. The impact of ROS on the miRNA expression and the role of the ROS/miRNA feedback regulation in the cell redox state are discussed. © 2019, Pleiades Publishing, Ltd.

Number of issue
11
Language
English
Pages
1233-1246
Status
Published
Volume
84
Year
2019
Organizations
  • 1 Peoples’ Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
Keywords
cellular redox homeostasis; microRNA; reactive oxygen species
Date of creation
24.12.2019
Date of change
24.12.2019
Short link
https://repository.rudn.ru/en/records/article/record/54918/
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