Peptides Selected Using Phage Library Variants, Effectively Inhibit Trypanosoma cruzi Infection

Four peptide sequences characterized by high content of hydrophobic, charged, and polar amino acids were obtained from 23 clones of M13 phage. Peptides P2 and P4 exhibited highest binding affinity for immobilized trypomastigotes. The inhibitory effects of peptides seemed to be due to blockade of certain epitopes on T. cruzi surface proteins responsible for interactions with the respective receptors of host cells. © 2017, Springer Science+Business Media, LLC.

Authors
Kleshchenko Y.E.1 , Zhigunova A.V. 1 , Dalin M.V. 1 , Melnikov V.2
Journal
Bulletin of Experimental Biology and Medicine
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
3
Language
English
Pages
361-364
Status
Published
Link
External link
DOI
10.1007/s10517-017-3804-0
Volume
163
Year
2017
Organizations
  • 1 Department of Microbiology and Virology, Medical Institute, Peopleэs Friendship University of Russia, Moscow, Russian Federation
  • 2 Laboratory of Molecular Biology, School of Medicine, University of Colima, Colima, Mexico
Keywords
anti-infectious activity; peptides; Trypanosoma cruzi
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/5457/
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