Comparative Analysis on the Effect of Plantago Species Aqueous Extracts on Tissue Trace Element Content in Rats

The primary objective of this study is to assess the influence of water extracts of Plantago major L., Plantago lanceolata L., and Plantago maxima Juss. ex Jacq. leaves on tissue trace element content in healthy adult Wistar rats. Twenty-eight female Wistar rats consumed pure drinking water or one of the three aqueous extracts of Plantago for 1 month. The extracts and liver, serum, hair, and adipose tissue of the rats were examined for trace element contents using inductively coupled plasma mass spectrometry. The aqueous extracts of Plantago species contained significant levels of trace elements, which were highest in P. lanceolata and P. major. The administration of every extract led to an increase in V and Si levels in the rats. At the same time, the consumption of P. lanceolata aqueous extract resulted in the accumulation of toxic elements (As, Pb) in the rats’ tissues. Despite the rather high concentration of heavy metals in the P. major leaf extract, its administration did not result in the accumulation of these elements. In turn, P. maxima extract induced a significant decrease in the tissue levels of Al, Cr, I, Li, and Mn in the rats. The beneficial effect of the P. major and P. maxima preparations may be at least partially associated with the increased supply of essential trace elements, whereas the use of P. lanceolata may be harmful due to the possibility of heavy metal overexposure. © 2017, Springer Science+Business Media New York.

Authors
Gatiatulina E.R.1, 2 , Nemereshina O.N.1 , Suliburska J.3 , Nagaraja T.P.4 , Skalnaya A.A.5 , Nikonorov A.A.1, 6 , Skalny A.V. 6, 7, 8, 9 , Tinkov A.A. 1, 6, 7, 8
Journal
Biological Trace Element Research
Publisher
Humana Press Inc.
Number of issue
1
Language
English
Pages
79-90
Status
Published
Link
External link
DOI
10.1007/s12011-017-0940-3
Volume
179
Year
2017
Organizations
  • 1 Orenburg State Medical University, Sovetskaya St., 6, Orenburg, 460000, Russian Federation
  • 2 South Ural State Medical University, Vorovskogo St., 64, Chelyabinsk, 454048, Russian Federation
  • 3 Poznan University of Life Sciences, Wojska Polskiego St.28, Poznan, Poland
  • 4 School of Energy and Environment, Thapar University, Patiala, 147004, India
  • 5 Lomonosov Moscow State University, Lomonosovsky Prospekt, 31-5, Moscow, 117192, Russian Federation
  • 6 Orenburg State University, Pobedy Avenue, 13, Orenburg, 460018, Russian Federation
  • 7 RUDN University, Miklukho-Maklay St., 10/2, Moscow, 117198, Russian Federation
  • 8 Yaroslavl State University, Sovetskaya St., 14, Yaroslavl, 150000, Russian Federation
  • 9 All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina St., 7, Moscow, 117216, Russian Federation
Keywords
Adipose tissue; Metals; Plantago; Silicon; Vanadium
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/5382/
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ORGANIC CHEMISTRY. HISTORY AND MUTUAL RELATIONS OF UNIVERSITIES OF RUSSIA

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Antipin I.S., Kazymova M.A., Kuznetsov M.A., Vasilyev A.V., Ishchenko M.A., Kiryushkin A.A., Kuznetsova L.M., Makarenko S.V., Ostrovskii V.A., Petrov M.L., Solod O.V., Trishin Y.G., Yakovlev I.P., Nenaidenko V.G., Beloglazkina E.K., Beletskaya I.P., Ustynyuk Y.A., Solov’ev P.A., Ivanov I.V., Malina E.V., Sivova N.V., Negrebetskii V.V., Baukov Y.I., Pozharskaya N.A., Traven’ V.F., Shchekotikhin A.E., Varlamov A.V., Borisova T.N., Lesina Y.A., Krasnokutskaya E.A., Rogozhnikov S.I., Shurov S.N., Kustova T.P., Klyuev M.V., Khelevina O.G., Stuzhin P.A., Fedorov A.Y., Gushchin A.V., Dodonov V.A., Kolobov A.V., Plakhtinskii V.V., Orlov V.Y., Kriven’ko A.P., Fedotova O.V., Pchelintseva N.V., Charushin V.N., Chupakhin O.N., Klimochkin Y.N., Klimochkina A.Y., Kuryatnikov V.N., Malinovskaya Y.A., Levina A.S., Zhuravlev O.E., Voronchikhina L.I., Fisyuk A.S., Aksenov A.V., Aksenov N.A., Aksenova I.V.
Russian Journal of Organic Chemistry. Vol. 53. 2017.