The influence of organic solvents on the epigenetic regulation of gene expression

In this study we screened 22 organic solvents for epigenetic activity using the HeLa TI model system. We demonstrated that acetone, acetonitrile, methanol, mercaptoethanol, DMSO and toluene affect epigenetic mechanisms of acetylation and methylation of H3 and H4 histones, thereby participating in the regulation of gene expression. The mechanism of chloroform epigenetic action is most likely not associated with histone modifications.

Authors
Maximova V.P.1 , Lizogub O.P.2 , Fedorov D.A.2 , Zhidkova E.M.1 , Lesovaya E.A.1, 3 , Kholodova A.V.1 , Belitsky G.A.1 , Yakubovskaya M.G.1 , Kirsanov K.I. 1, 4
Conference proceedings
The 22nd International Charles Heidelberger Symposium on Cancer Research
Publisher
Национальный исследовательский Томский государственный университет
Language
English
Pages
68-70
Status
Published
Year
2018
Organizations
  • 1 Blokhin NMRCO, Department of Chemical Carcinogenesis
  • 2 First Moscow State Medical University
  • 3 Ryazan State Medical University
  • 4 RUDN University
Keywords
organic solvents; epigenetic activity; HeLa TI
Date of creation
07.11.2019
Date of change
07.11.2019
Short link
https://repository.rudn.ru/en/records/article/record/53186/
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Article
Fetisov T.I., Kuzin K.A., Zenkov R.G., Safina A., Lesovaya E.A., Trukhanova L.S., Antoshina E.E., Gorkova T.G., Gurova K., Yakubovskaya M.G., Kirsanov K.I.
The 22nd International Charles Heidelberger Symposium on Cancer Research. Национальный исследовательский Томский государственный университет. 2018. P. 29-30